Cardiohepatic Syndrome among Heart Failure Patients in Yemen

Authors

  • Dr. Shawqi Hussein Nagi Al-Awdi 21 September University for Medical and Applied Sciences Author
  • Ahmed Ebrahim Ali Alkhuli 21 September University for Medical and Applied Sciences Author
  • Aseel Abdul-Jabbar Saleh Rishan 21 September University for Medical and Applied Sciences Author
  • Ibrahim Abdullah Baker 21 September University for Medical and Applied Sciences Author
  • Aseel Abdulhalim Ali. khawez 21 September University for Medical and Applied Sciences Author
  • Osama Hassan Al Quaish 21 September University for Medical and Applied Sciences Author
  • Asala Abdulhalim Gasem khawez 21 September University for Medical and Applied Sciences Author
  • Ghadah Adel Mutahar Badi Author
  • Sara Abdulaziz Alboukair 21 September University for Medical and Applied Sciences Author
  • Abeer Mohammed Qasem Mahdi 21 September University for Medical and Applied Sciences Author
  • Lamia Mahmoud Modhish 21 September University for Medical and Applied Sciences Author
  • Tariq Ali Mohammed Al Sayaghi 21 September University for Medical and Applied Sciences Author
  • Haitham Hamis Abdullah Qasim 21 September University for Medical and Applied Sciences Author
  • Noor Ali salam Alazazi 21 September University for Medical and Applied Sciences Author

DOI:

https://doi.org/10.65693/irss.2022.v3i1.305

Keywords:

cardiohepatic sndromeإزالة cardiohepatic sndrome cross sectional study in sanaa yemen

Abstract

Cardiohepatic Syndrome among Heart Failure Patients in Yemen Aims of the study: The present study was aimed to investigate the clinical patterns of cardiohepatic syndrome among patients with heart failure attending several private and public hospitals in Sana’a city, Yemen.

Methods: The study was a clinical cross-sectional study performed on patients with heart failure admitted to the medical departments at several private and public hospitals in Sana’a city between July 1, 2021 and December 31, 2021.

Results: A total of 162 diagnosed cases of cardiohepatic syndrome were studied. Male patients were 117 (72.2%) and female patients were 45 (27.8%). The age of patients with cardiohepatic syndrome ranged between 0.5 and 81 years. The results of the present study showed that most patients with cardiohepatic syndrome aged between 41 and 70 years (66.1%). Most cardiohepatic syndrome patients were admitted to Lebanon hospital (75.3%) followed by Althawra hospital (10.5%). Patients with cardiohepatic syndrome most frequently presented with edema (56.2%), pallor (40.7%), and cyanosis (25.3%). Other less frequent sings were icterus (8.6%) and clubbing (8%). The average pulse rates in cardiohepatic syndrome patients was 94 ppm (maximum 142 and 37 minimum), the average systolic blood pressure was 118mmHg (maximum 200 and 60 minimum), and the average diastolic blood pressure was 75 mmHg (maximum 120 and minimum 40). The laboratory investigations that were performed for the patients to assess liver function included Total bilirubin, Direct bilirubin, Indirect bilirubin, AST, ALT, ALP, Total protein, Albumin, Prothrombin time, and Activated partial thromboplastin time. Additionally, routine complete blood count and kidney function tests were performed. Large proportion of patients (55.7%) had heart failure with preserved ejection fraction (HFpEF) while 28.2% of the patients had heart failure with reduced ejection fraction (HFrEF). Minority (9.9%) of the patients had heart failure with mid-range ejection fraction (HFmrEF) and 6.1% of the patients had normal ejection fraction.

Conclusions: Cardiohepatic syndrome presents with a full-range of signs,

 

symptoms, and lab test deviations, and is more prevalent in male, middle-aged heart failure patients. Cardiohepatic syndrome is also more likely in patients with reduced ejection fraction.

References

References

1. Khadem E., Toosi M.N., Ilkhani R. Liver- Heart Inter- Relationship in Fatty Liver Disease Based on the Avicenna’s Point of View. Iran. J. Public Health. 2013;42:648–649. [PMC free article] [PubMed] [Google Scholar]

2. Asrani N.S., Freese D.K., Phillips S.D., Heimbach J., Asrani S.K., Warnes C.A., Kamath P.S. Congenital heart disease and the liver. Hepatology. 2012;56:1160–1169. doi: 10.1002/hep.25692. [PubMed] [CrossRef] [Google Scholar]

3. Giallourakis C.C., Rosenberg P.M., Friedman L.S. The liver in heart failure. Clin. Liver Dis. 2002;6:947–967. doi: 10.1016/S1089-3261(02)00056-9. [PubMed]

[CrossRef] [Google Scholar]

4. De Gonzalez A.K.K., Lefkowitch J.H. Heart Disease and the Liver. Gastroenterol. Clin. N. Am. 2017;46:421–435. doi: 10.1016/j.gtc.2017.01.012. [PubMed] [CrossRef] [Google Scholar]

5. Myers R.P., Cerini R., Sayegh R., Moreau R., Degott C., Lebrec D., Lee S.S. Cardiac hepatopathy: Clinical, hemodynamic, and histologic characteristics and correlations. Hepatology. 2003;37:393–400. doi: 10.1053/jhep.2003.50062. [PubMed] [CrossRef] [Google Scholar]

6. Téllez L., Rodriguez-Santiago E., Albillos A. Fontan-Associated Liver Disease: A Review. Ann. Hepatol. 2018;17:192–204. doi: 10.5604/01.3001.0010.8634. [PubMed] [CrossRef] [Google Scholar]

7. Fauci A.S., Braunwald E., Hauser S.L., Longo D.L., Jameson J., Loscalzo

J. Harrison’s Principles of Internal Medicine. Volume 2 McGraw-Hill Medical; New York, NY, USA: 2008. [Google Scholar]

8. Kiesewetter C.H., Sheron N., Vettukattill J.J., Hacking N., Stedman B., Millward-Sadler H., Haw M., Cope R., Salmon A.P., Sivaprakasam M.C., et al. Hepatic changes in the failing Fontan circulation. Heart. 2006;93:579–584. doi: 10.1136/hrt.2006.094516. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

9. Weisberg I.S., Jacobson I.M. Cardiovascular Diseases and the Liver. Clin. Liver Dis. 2011;15:1–20. doi: 10.1016/j.cld.2010.09.010. [PubMed] [CrossRef] [Google Scholar]

10. Vasconcelos L.A.B.A., De Almeida E.A., Bachur L.F. Clinical evaluation and hepatic laboratory assessment in individuals with congestive heart failure. Arq. Bras. Cardiol. 2007;88:590–595. doi: 10.1590/S0066-782X2007000500015. [PubMed] [CrossRef] [Google Scholar]

11. Poelzl G., Eberl C., Achrainer H., Doerler J., Pachinger O., Frick M., Ulmer H. Prevalence and Prognostic Significance of Elevated γ-Glutamyltransferase in Chronic Heart Failure. Circ. Heart Fail. 2009;2:294–302.

doi: 10.1161/CIRCHEARTFAILURE.108.826735. [PubMed] [CrossRef] [Google

Scholar]

12. Fuhrmann V., Jäger B., Zubkova A., Drolz A. Hypoxic hepatitis – epidemiology, pathophysiology and clinical management. Wien. Klin. Wochenschr. 2010;122:129–139. doi: 10.1007/s00508-010-1357-6. [PubMed]

[CrossRef] [Google Scholar]

13. Dunn G.D., Hayes P., Breen K.J., Schenker S. The liver in congestive heart failure: A review. Am. J. Med. Sci. 1973;265:174–189. doi: 10.1097/00000441-197303000-00001. [PubMed] [CrossRef] [Google Scholar]

14. Shah H., Kuehl K., Sherker A.H. Liver Disease After the Fontan Procedure. J. Clin. Gastroenterol. 2010;44:1.

doi: 10.1097/MCG.0b013e3181d476fc. [PubMed] [CrossRef] [Google Scholar]

15. Wells M.L., Fenstad E.R., Poterucha J.T., Hough D.M., Young P.M., Araoz P.A., Ehman R.L., Venkatesh S.K. Imaging Findings of Congestive Hepatopathy. Radiographics. 2016;36:1024–1037.

doi: 10.1148/rg.2016150207. [PubMed] [CrossRef] [Google Scholar]

16. Dai D.-F., Swanson P., Krieger E., Liou I.W., Carithers R.L., Yeh M.M. Congestive hepatic fibrosis score: A novel histologic assessment of clinical severity. Mod. Pathol. 2014;27:1552–1558. doi: 10.1038/modpathol.2014.79. [PubMed] [CrossRef] [Google Scholar]

17. Sherlock S. The Liver in Heart Failure Relation of Anatomical, Functional, and Circulatory Changes. Heart. 1951;13:273–293. doi: 10.1136/hrt.13.3.273. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

18. Maleki M., Vakilian F., Amin A. Liver diseases in heart failure. Heart Asia. 2011;3:143–149. [PMC free article] [PubMed] [Google Scholar]

19. Russell S.D., Rogers J., Milano C.A., Dyke D.B., Pagani F.D., Aranda J.M., Klodell C.T., Boyle A.J., John R., Chen L., et al. Renal and Hepatic Function Improve in Advanced Heart Failure Patients During Continuous-Flow Support With the HeartMate II Left Ventricular Assist Device. Circulation. 2009;120:2352–2357.

doi: 10.1161/CIRCULATIONAHA.108.814863. [PubMed] [CrossRef] [Google Scholar]

20. Dichtl W., Vogel W., Dunst K.M., Grander W., Alber H.F., Frick M., Antretter H., Laufer G., Pachinger O., Pölzl G. Cardiac hepatopathy before and after heart. transplantation. Transpl. Int. 2005;18:697–702. doi: 10.1111/j.1432-2277.2005.00122.x. [PubMed] [CrossRef] [Google Scholar]

21. Seeto R.K., Fenn B., Rockey D.C. Ischemic hepatitis: Clinical presentation and pathogenesis. Am. J. Med. 2000;109:109–113. doi: 10.1016/S0002-

9343(00)00461-7. [PubMed] [CrossRef] [Google Scholar]

22. Harjola V.-P., Mullens W., Banaszewski M., Bauersachs J., Rocca H.-P.B.-L., Chioncel O., Collins S.P., Doehner W., Filippatos G.S., Flammer A., et al. Organ dysfunction, injury and failure in acute heart failure: From pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) Eur. J. Heart Fail. 2017;19:821–836. doi: 10.1002/ejhf.872. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

23. Eipel C., Abshagen K., Vollmar B. Regulation of hepatic blood flow: The hepatic arterial buffer response revisited. World J. Gastroenterol. 2010;16:6046–6057. doi: 10.3748/wjg.v16.i48.6046. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

24. Henrion J., Descamps O., Luwaert R., Schapira M., Parfonry A., Heller F. Hypoxic hepatitis in patients with cardiac failure: Incidence in a coronary care unit and measurement of hepatic blood flow. J. Hepatol. 1994;21:696–703. doi: 10.1016/S0168-8278(94)80226-2. [PubMed] [CrossRef] [Google Scholar]

25. Naschitz J.E., Yeshurun D., Shahar J. Cardiogenic Hepatorenal Syndrome. Angiology. 1990;41:893–900.

doi: 10.1177/000331979004101101. [PubMed] [CrossRef] [Google Scholar]

26. Birrer R., Takuda Y., Takara T. Hypoxic hepatopathy: Pathophysiology and prognosis. Intern. Med. 2007;46:1063–1070. doi: 10.2169/internalmedicine.46.0059. [PubMed] [CrossRef] [Google Scholar]

27. Henrion J., Schapira M., Luwaert R., Colin L., Delannoy A., Heller F.R. Hypoxic hepatitis: Clinical and hemodynamic study in 142 consecutive cases. Medicine. 2003;82:392–406.

doi: 10.1097/01.md.0000101573.54295.bd. [PubMed] [CrossRef] [Google Scholar]

28. Denis C., De Kerguennec C., Bernuau J., Beauvais F., Cohen-Solal A. Acute hypoxic hepatitis (‘liver shock’): Still a frequently overlooked cardiological diagnosis. Eur. J. Heart Fail. 2004;6:561–565. doi: 10.1016/j.ejheart.2003.12.008. [PubMed] [CrossRef] [Google Scholar]

29. Giannini E.G., Testa R., Savarino V. Liver enzyme alteration: A guide for clinicians. Can. Med. Assoc. J. 2005;172:367–379. doi: 10.1503/cmaj.1040752. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

30. Cassidy W.M., Reynolds T.B. Serum Lactic Dehydrogenase in the Differential Diagnosis of Acute Hepatocellular Injury. J. Clin. Gastroenterol. 1994;19:118–121. doi: 10.1097/00004836-199409000-

00008. [PubMed] [CrossRef] [Google Scholar]

31. Alvarez A.M., Mukherjee D. Liver Abnormalities in Cardiac Diseases and Heart Failure. Int. J. Angiol. 2011;20:135–142. doi: 10.1055/s-0031-1284434. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

32. De La Monte S.M., Arcidi J.M., Moore G.W., Hutchins G.M. Midzonal Necrosis as a Pattern of Hepatocellular Injury After Shock. Gastroenterology. 1984;86:627–631. doi: 10.1016/S0016-5085(84)80109-2. [PubMed] [CrossRef] [Google Scholar]

33. Waseem N., Chen P.-H. Hypoxic Hepatitis: A Review and Clinical Update. J. Clin. Transl. Hepatol. 2016;4:263–268. [PMC free article] [PubMed] [Google Scholar]

34. Limas C.J., Guiha N.H., Lekagul O., Cohn J.N. Impaired Left Ventricular Function in Alcoholic Cirrhosis with Ascites. Circulation. 1974;49:755–760. doi: 10.1161/01.CIR.49.4.755. [PubMed] [CrossRef] [Google Scholar]

35. Møller S., Henriksen J.H. Cirrhotic cardiomyopathy. J. Hepatol. 2010;53:179–190. doi: 10.1016/j.jhep.2010.02.023. [PubMed] [CrossRef] [Google Scholar]

36. Alqahtani S.A., Fouad T.R., Lee S.S. Cirrhotic Cardiomyopathy. Semin. Liver Dis. 2008;28:59–69. doi: 10.1055/s-2008-1040321. [PubMed]

[CrossRef] [Google Scholar]

37. Wiese S., Hove J., Bendtsen F., Møller S. Cirrhotic cardiomyopathy: Pathogenesis and clinical relevance. Nat. Rev. Gastroenterol. Hepatol. 2013;11:177–186. doi: 10.1038/nrgastro.2013.210. [PubMed] [CrossRef] [Google Scholar]

38. Goldberg D., Fallon M.B. The Art and Science of Diagnosing and Treating Lung and Heart Disease Secondary to Liver Disease. Clin. Gastroenterol. Hepatol. 2015;13:2118–2127. doi: 10.1016/j.cgh.2015.04.024. [PMC free

article] [PubMed] [CrossRef] [Google Scholar]

39. Bolognesi M., Di Pascoli M., Verardo A., Gatta A. Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis. World J. Gastroenterol. 2014;20:2555–2563. doi: 10.3748/wjg.v20.i10.2555. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

40. Møller S. Cirrhotic cardiomyopathy: A pathophysiological review of circulatory dysfunction in liver disease. Heart. 2002;87:9–15. doi: 10.1136/heart.87.1.9. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

41. Henriksen J.H., Fuglsang S., Bendtsen F., Christensen E., Møller S. Arterial compliance in patients with cirrhosis: Stroke volume-pulse pressure ratio as simplified index. Am. J. Physiol. Liver Physiol. 2001;280:G584–G594. doi: 10.1152/ajpgi.2001.280.4.G584. [PubMed] [CrossRef] [Google Scholar]

42. Dümcke C.W., Møller S. Autonomic dysfunction in cirrhosis and portal

hypertension. Scand. J. Clin. Lab. Investig. 2008;68:437–447. doi: 10.1080/00365510701813096. [PubMed] [CrossRef] [Google Scholar]

43. Kelbæk H., Rabøl A., Brynjolf I., Eriksen J., Bonnevie O., Godtfredsen J., Munck O., Lund J.O. Haemodynamic response to exercise in patients with alcoholic liver cirrhosis. Clin. Physiol. 1987;7:35–41. doi: 10.1111/j.1475-097X.1987.tb00631.x. [PubMed] [CrossRef] [Google Scholar]

44. Møller S., Dümcke C.W., Krag A. The heart and the liver. Expert. Rev. Gastroenterol. Hepatol. 2009;3:51–64.

doi: 10.1586/17474124.3.1.51. [PubMed] [CrossRef] [Google Scholar]

45. Lee S.S., Marty J., Mantz J., Samain E., Braillon A., Lebrec D. Desensitization of myocardial beta-adrenergic receptors in cirrhotic rats. Hepatology. 1990;12:481–485. doi: 10.1002/hep.1840120306. [PubMed] [CrossRef] [Google Scholar]

46. Hausdorff W.P., Caron M.G., Lefkowitz R.J. Turning off the signal: Desensitization of beta-adrenergic receptor function. FASEB

J. 1990;4:2881–2889. doi: 10.1096/fasebj.4.11.2165947. [PubMed]

[CrossRef] [Google Scholar]

47. Van Obbergh L., Vallieres Y., Blaise G. Cardiac modifications occurring in the ascitic rat with biliary cirrhosis are nitric oxide related. J. Hepatol. 1996;24:747–752. doi: 10.1016/S0168-8278(96)80272-8. [PubMed]

[CrossRef] [Google Scholar]

48. Liu H., Ma Z., Lee S.S. Contribution of nitric oxide to the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Gastroenterology. 2000;118:937–944. doi: 10.1016/S0016-5085(00)70180-6. [PubMed] [CrossRef] [Google Scholar]

49. Gaskari S.A., Liu H., Moezi L., Li Y., Baik S.K., Lee S.S. Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Br. J. Pharmacol. 2005;146:315–323. doi: 10.1038/sj.bjp.0706331. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

50. Basu P.P., Aloysius M.M., Shah N.J., Brown R.S., Jr. Review article: The endocannabinoid system in liver disease, a potential therapeutic target. Aliment. Pharmacol. Ther. 2014;39:790–801. doi: 10.1111/apt.12673. [PubMed] [CrossRef] [Google Scholar]

51. Bátkai S., Mukhopadhyay P., Harvey-White J., Kechrid R., Pacher P., Kunos G. Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats. Am. J. Physiol. Circ. Physiol. 2007;293:H1689–H1695. doi: 10.1152/ajpheart.00538.2007. [PMC

free article] [PubMed] [CrossRef] [Google Scholar]

52. Yang Y.Y., Liu H., Nam S.W., Kunos G., Lee S.S. Mechanisms of TNF α-

induced cardiac dysfunction in cholestatic bile ductligated mice: Interaction between TNF α and endocannabinoids. J. Hepatol. 2010;53:298–306. doi: 10.1016/j.jhep.2010.03.011. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

53. Nayor M., Cooper L.L., Enserro D.M., Xanthakis V., Larson M.G., Benjamin E.J., Aragam J., Mitchell G.F., Vasan R.S. Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis. J. Am. Heart Assoc. 2018;7:e008291. doi: 10.1161/JAHA.117.008291. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

54. Baik S.K., Fouad T.R., Lee S.S. Cirrhotic cardiomyopathy. Orphanet J. Rare Dis. 2007;2:15. doi: 10.1186/1750-1172-2-15. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

55. Glenn T.K., Honar H., Liu H., Ter Keurs H.E., Lee S.S. Role of cardiac myofilament proteins titin and collagen in the pathogenesis of diastolic dysfunction in cirrhotic rats. J. Hepatol. 2011;55:1249–1255. doi: 10.1016/j.jhep.2011.02.030. [PubMed] [CrossRef] [Google Scholar]

56. Li M.X., Hwang P.M. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015;571:153–166. doi: 10.1016/j.gene.2015.07.074. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

57. Kim S.M., George B., Alcivar-Franco D., Campbell C.L., Charnigo R., Delisle B., Hundley J., Darrat Y., Morales G., Elayi S.-C., et al. QT prolongation is associated with increased mortality in end stage liver disease. World J. Cardiol. 2017;9:347–354. doi: 10.4330/wjc.v9.i4.347. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

58. Țieranu E., Donoiu I., Istrătoaie O., Găman A., Țieranu L., Gheonea D., Ciurea T. Q-T Interval Prolongation in Patients with Liver Cirrhosis. Curr. Health Sci.

J. 2018;44:274–279. [PMC free article] [PubMed] [Google Scholar]

59. Genovesi S., Pizzala D.M.P., Pozzi M., Ratti L., Milanese M., Pieruzzi F.U.E.G., Vincenti A., Stella A., Mancia G., Stramba-Badiale M. QT interval prolongation and decreased heart rate variability in cirrhotic patients: Relevance of hepatic venous pressure gradient and serum calcium. Clin. Sci. 2009;116:851–859. doi: 10.1042/CS20080325. [PubMed] [CrossRef] [Google Scholar]

60. Hendrickse M., Triger D. Peripheral and cardiovascular autonomic impairment in chronic liver disease: Prevalence and relation to hepatic function. J. Hepatol. 1992;16:177–183. doi: 10.1016/S0168-8278(05)80112-

6. [PubMed] [CrossRef] [Google Scholar]

61. Licata A., Novo G., Colomba D., Tuttolomondo A., Galia M., Cammà C. Cardiac involvement in patients with cirrhosis. J. Cardiovasc. Med. 2016;17:26–36.

doi: 10.2459/JCM.0000000000000288. [PubMed] [CrossRef] [Google Scholar]

62. Wiese S., Mortensen C., Gøtze J.P., Christensen E., Andersen O., Bendtsen F., Møller S. Cardiac and proinflammatory markers predict prognosis in cirrhosis. Liver Int. 2014;34:e19–e30. doi: 10.1111/liv.12428. [PubMed] [CrossRef] [Google Scholar]

63. Møller S., Danielsen K.V., Wiese S., Hove J., Bendtsen F. An update on cirrhotic cardiomyopathy. Expert Rev. Gastroenterol. Hepatol. 2019;13:497–505. doi: 10.1080/17474124.2019.1587293. [PubMed]

[CrossRef] [Google Scholar]

64. Liu H., Jayakumar S., Traboulsi M., Lee S.S. Cirrhotic cardiomyopathy: Implications for liver transplantation. Liver Transplant. 2017;23:826–835. doi: 10.1002/lt.24768. [PubMed] [CrossRef] [Google Scholar]

65. Schnell F., Donal E., Lorho R., Lavoué S., Gacouin A., Compagnon P., Boudjema K., Mabo P., Le Tulzo Y., Camus C. Severe left-sided heart failure early after liver transplantation. Liver Transplant. 2009;15:1296–1305. doi: 10.1002/lt.21822. [PubMed] [CrossRef] [Google Scholar]

66. Dote K., Sato H., Tateishi H., Uchida T., Ishihara M. [Myocardial stunning due to simultaneous multivessel coronary spasms: A review of 5 cases] J. Cardiol. 1991;21:203–214. [PubMed] [Google Scholar]

67. Saner F.H., Plicht B., Treckmann J., Máthé Z., Sotiropoulos G.C., Radtke A., Beckebaum S., Cicinnati V., Paul A. Tako-Tsubo syndrome as a rare cause of cardiac failure in liver transplantation. Liver Int. 2010;30:159–160. doi: 10.1111/j.1478-3231.2009.02062.x. [PubMed] [CrossRef] [Google Scholar]

68. Bainbridge D., Cheng D. Stress-induced cardiomyopathy in the perioperative setting. Can. J. Anesth. 2009;56:397–401. doi: 10.1007/s12630-009-9085-

y. [PubMed] [CrossRef] [Google Scholar]

69. Pilgrim T., Wyss T. Takotsubo cardiomyopathy or transient left ventricular apical ballooning syndrome: A systematic review. Int. J. Cardiol. 2008;124:283–292. doi: 10.1016/j.ijcard.2007.07.002. [PubMed] [CrossRef] [Google Scholar]

70. Tomescu D.R., Tulbure D., Dima S., Ungureanu D., Popescu M., Popescu I. First Report of Cytokine Removal using CytoSorb® in Severe Noninfectious Inflammatory Syndrome after Liver Transplantation. Int. J. Artif. Organs. 2016;39:136–140. doi: 10.5301/ijao.5000489. [PubMed] [CrossRef] [Google Scholar]

71. Sato H., Taiteishi H., Uchida T. Takotsubo-type cardiomyopathy due to multivessel spasm. In: Kodama K., Haze K., Hon M., editors. Clinical Aspect of Myocardial Injury: From Ischemia to Heart Failure. Kagakuhyouronsha; Tokyo, Japan: 1990. pp. 56–64. [Google Scholar]

72. Nakano T., Onoue K., Nakada Y., Nakagawa H., Kumazawa T., Ueda T., Nishida T., Soeda T., Okayama S., Watanabe M., et al. Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: A Human Study. Sci. Rep. 2018;8:12731. doi: 10.1038/s41598-018

-31034-z. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

73. Sandhu G., Servetnyk Z., Croitor S., Herzog E. Atropine aggravates signs and symptoms of Takotsubo cardiomyopathy. Am. J. Emerg. Med. 2010;28:258.e5–258.e7. doi: 10.1016/j.ajem.2009.06.011. [PubMed]

[CrossRef] [Google Scholar]

74. Fouad T.R., Abdel-Razek W., Burak K.W., Bain V.G., Lee S.S. Prediction of Cardiac Complications After Liver Transplantation. Transplantation. 2009;87:763–770.

doi: 10.1097/TP.0b013e318198d734. [PubMed] [CrossRef] [Google Scholar]

75. Josefsson A., Fu M., Allayhari P., Björnsson E.S., Castedal M., Olausson M., Kalaitzakis E. Impact of peri-transplant heart failure & left-ventricular diastolic dysfunction on outcomes following liver transplantation. Liver Int. 2012;32:1262–1269. [PubMed] [Google Scholar]

76. Sonny A., Ibrahim A., Schuster A., Jaber W.A., Cywinski J.B. Impact and persistence of cirrhotic cardiomyopathy after liver transplantation. Clin. Transplant. 2016;30:986–993. doi: 10.1111/ctr.12778. [PubMed] [CrossRef] [Google Scholar]

77. Qureshi W., Mittal C., Ahmad U., Alirhayim Z., Hassan S., Qureshi S., Khalid F. Clinical predictors of post-liver transplant new-onset heart failure. Liver Transplant. 2013;19:701–710. doi: 10.1002/lt.23654. [PubMed] [CrossRef] [Google Scholar]

78. Albeldawi M., Aggarwal A., Madhwal S., Cywinski J., Lopez R., Eghtesad B., Zein N.N. Cumulative risk of cardiovascular events after orthotopic liver transplantation. Liver Transplant. 2012;18:370–375. doi: 10.1002/lt.22468. [PubMed] [CrossRef] [Google Scholar]

79. Ikegami T., Shirabe K., Soejima Y., Taketomi A., Yoshizumi T., Uchiyama H., Harada N., Maehara Y. The impact of renal replacement therapy before or after living donor liver transplantation. Clin. Transplant. 2011;26:143–148. doi: 10.1111/j.1399-0012.2011.01450.x. [PubMed] [CrossRef] [Google Scholar]

80. Sehgal L., Srivastava P., Pandey C.K., Jha A. Preoperative cardiovascular investigations in liver transplant candidate: An update. Indian J. Anaesth. 2016;60:12–18. doi: 10.4103/0019-5049.174870. [PMC free

article] [PubMed] [CrossRef] [Google Scholar]

81. Sattar Y., Siew K.S.W., Connerney M., Ullah W., Alraies M.C. Management of Takotsubo Syndrome: A Comprehensive Review. Cureus. 2020;12:e6556.

doi: 10.7759/cureus.6556. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

82. Petäjä E.M., Yki-Järvinen H. Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD—A Systematic Review. Int. J. Mol. Sci. 2016;17:633. doi: 10.3390/ijms17050633. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

83. Kanwar P., Kowdley K.V. The Metabolic Syndrome and Its Influence on Nonalcoholic Steatohepatitis. Clin. Liver Dis. 2016;20:225–243. doi: 10.1016/j.cld.2015.10.002. [PubMed] [CrossRef] [Google Scholar]

84. Ipsen D.H., Lykkesfeldt J., Tveden-Nyborg P. Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. Cell. Mol. Life Sci. 2018;75:3313–3327. doi: 10.1007/s00018-018-2860-6. [PMC free

article] [PubMed] [CrossRef] [Google Scholar]

85. Ekstedt M., Hagström H., Nasr P., Fredrikson M., Stal P., Kechagias S., Hultcrantz R. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology. 2015;61:1547–1554. doi: 10.1002/hep.27368. [PubMed] [CrossRef] [Google Scholar]

86. Angulo P., Kleiner D.E., Dam-Larsen S., Adams L.A., Björnsson E.S., Charatcharoenwitthaya P., Mills P.R., Keach J.C., Lafferty H.D., Stahler A., et al. Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2015;149:389–397.e10.

doi: 10.1053/j.gastro.2015.04.043. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

87. Motamed N., Rabiee B., Poustchi H., Dehestani B., Hemmasi G.R., Khansari M., Maadi M., Saeedian F.S., Zamani F. Non-alcoholic fatty liver disease (NAFLD) and 10-year risk of cardiovascular diseases. Clin. Res. Hepatol. Gastroenterol. 2017;41:31–38. doi: 10.1016/j.clinre.2016.07.005. [PubMed] [CrossRef] [Google Scholar]

88. Haddad T.M., Hamdeh S., Kanmanthareddy A., Alla V.M. Nonalcoholic fatty liver disease and the risk of clinical cardiovascular events: A systematic review and meta-analysis. Diabetes Metab. Syndr. Clin. Res. Rev. 2017;11:S209–S216. doi: 10.1016/j.dsx.2016.12.033. [PubMed]

[CrossRef] [Google Scholar]

89. Assy N.N., Djibre A., Farah R., Grosovski M., Marmor A. Presence of Coronary Plaques in Patients with Nonalcoholic Fatty Liver Disease

1. Radiology. 2010;254:393–400. doi: 10.1148/radiol.09090769. [PubMed] [CrossRef] [Google Scholar]

90. Pinarbasi B., Demir K., Oflaz H., Ahishali E., Akyuz F., Elitok A., Cimen A.O., Golcuk E., Gulluoglu M., Issever H., et al. Measurement of the coronary flow velocity reserve in patients with non-alcoholic fatty liver disease. Turk. J. Gastroenterol. 2012;23:720–726. doi: 10.4318/tjg.2012.0489. [PubMed] [CrossRef] [Google Scholar]

91. Wan S.-H., Vogel M.W., Chen H.H. Pre-clinical diastolic dysfunction. J. Am. Coll. Cardiol. 2013;63:407–416. doi: 10.1016/j.jacc.2013.10.063. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

92. Mantovani A., Zoppini G., Targher G., Golia G., Bonora E. Non-alcoholic fatty liver disease is independently associated with left ventricular hypertrophy in hypertensive Type 2 diabetic individuals. J. Endocrinol. Investig. 2012;35:215–218. doi: 10.1007/BF03345421. [PubMed]

[CrossRef] [Google Scholar]

93. Markus M.R.P., Baumeister S.E., Stritzke J., Dörr M., Wallaschofski H., Völzke H., Lieb W. Hepatic Steatosis Is Associated With Aortic Valve Sclerosis in the General Population. Arter. Thromb. Vasc. Boil. 2013;33:1690–1695. doi: 10.1161/ATVBAHA.112.300556. [PubMed] [CrossRef] [Google Scholar]

94. Mantovani A., Pernigo M., Bergamini C., Bonapace S., Lipari P., Valbusa F., Bertolini L., Zenari L., Pichiri I., Dauriz M., et al. Heart valve calcification in patients with type 2 diabetes and nonalcoholic fatty liver disease. Metabolism. 2015;64:879–887.

doi: 10.1016/j.metabol.2015.04.003. [PubMed] [CrossRef] [Google Scholar]

95. Mantovani A. Nonalcoholic Fatty Liver Disease (NAFLD) and Risk of Cardiac Arrhythmias: A New Aspect of the Liver-heart Axis. J. Clin. Transl. Hepatol. 2017;5:134–141. doi: 10.14218/JCTH.2017.00005. [PMC free

article] [PubMed] [CrossRef] [Google Scholar]

96. Tana C., Ballestri S., Ricci F., Di Vincenzo A., Ticinesi A., Gallina S., Giamberardino M.A., Cipollone F., Sutton R., Vettor R., et al. Cardiovascular Risk in Non-Alcoholic Fatty Liver Disease: Mechanisms and Therapeutic Implications. Int. J. Environ. Res. Public Health. 2019;16:3104. doi: 10.3390/ijerph16173104. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

97. Fotbolcu H., Zorlu E. Nonalcoholic fatty liver disease as a multi-systemic disease. World J. Gastroenterol. 2016;22:4079–4090. doi: 10.3748/wjg.v22.i16.4079. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

98. Gaziano J., Hennekens C.H., O’Donnell C.J., Breslow J.L., Buring J.E. Fasting Triglycerides, High-Density Lipoprotein, and Risk of Myocardial Infarction. Circulation. 1997;96:2520–2525.

doi: 10.1161/01.CIR.96.8.2520. [PubMed] [CrossRef] [Google Scholar]

99. Niederreiter L., Tilg H. Cytokines and fatty liver diseases. Liver Res. 2018;2:14–20. doi: 10.1016/j.livres.2018.03.003. [CrossRef] [Google Scholar]

100. Francque S., Van Der Graaff D., Kwanten W. Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications. J. Hepatol. 2016;65:425–443. doi: 10.1016/j.jhep.2016.04.005. [PubMed] [CrossRef] [Google Scholar]

101. Liu H., Lu H.-Y. Nonalcoholic fatty liver disease and cardiovascular disease. World J. Gastroenterol. 2014;20:8407–8415. doi: 10.3748/wjg.v20.i26.8407. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

102. Adolph T.E., Grander C., Grabherr F., Tilg H. Adipokines and Non-Alcoholic Fatty Liver Disease: Multiple Interactions. Int. J. Mol. Sci. 2017;18:1649. doi: 10.3390/ijms18081649. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

103. Tariq Z., Green C.J., Hodson L. Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non

-alcoholic steatohepatitis (NASH)? Liver Int. 2014;34:e180–e190. doi: 10.1111/liv.12523. [PubMed] [CrossRef] [Google Scholar]

104. Polimeni L., Del Ben M., Baratta F., Perri L., Albanese F., Pastori D., Violi F., Angelico F. Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis. World J. Hepatol. 2015;7:1325–1336. doi: 10.4254/wjh.v7.i10.1325. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

105. Semenkovich C.F. Insulin resistance and atherosclerosis. J. Clin. Investig. 2006;116:1813–1822. doi: 10.1172/JCI29024. [PMC free

article] [PubMed] [CrossRef] [Google Scholar]

106. Kotronen A., Joutsi-Korhonen L., Sevastianova K., Bergholm R., Hakkarainen A., Pietiläinen K.H., Lundbom N., Rissanen A., Lassila R., Yki-Järvinen H. Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease. Liver Int. 2010;31:176–183. doi: 10.1111/j.1478-3231.2010.02375.x. [PubMed] [CrossRef] [Google Scholar]

107. Loeffen R., Spronk H., Cate H.T. The impact of blood coagulability on atherosclerosis and cardiovascular disease. J. Thromb. Haemost. 2012;10:1207–1216. doi: 10.1111/j.1538-

7836.2012.04782.x. [PubMed] [CrossRef] [Google Scholar]

108. Verrijken A., Francque S., Mertens I., Prawitt J., Caron S., Hubens G., Van Marck E., Staels B., Michielsen P., Van Gaal L. Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Hepatology. 2013;59:121–129.

doi: 10.1002/hep.26510. [PubMed] [CrossRef] [Google Scholar]

109. Tofler G.H., Massaro J., O’Donnell C., Wilson P., Vasan R., Sutherland P., Meigs J., Levy D., D’Agostino R. Plasminogen activator inhibitor and the risk of cardiovascular disease: The Framingham Heart Study. Thromb. Res. 2016;140:30–35. doi: 10.1016/j.thromres.2016.02.002. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

110. Barb D., Bril F., Kalavalapalli S., Cusi K. Plasma Fibroblast Growth Factor 21 Is Associated with Severity of Nonalcoholic Steatohepatitis in Patients with Obesity and Type 2 Diabetes. J. Clin. Endocrinol. Metab. 2019;104:3327–3336. doi: 10.1210/jc.2018-02414. [PMC free

article] [PubMed] [CrossRef] [Google Scholar]

111. Chow W., Xu A., Woo Y.C., Tso A.W., Cheung S.C., Fong C.H., Tse H.-F.,

Chau M.T., Cheung B.M.Y., Lam K.S.L. Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors. Arter. Thromb. Vasc. Boil. 2013;33:2454–2459. doi: 10.1161/ATVBAHA.113.301599. [PubMed]

[CrossRef] [Google Scholar]

112. Shen Y., Ma X., Zhou J., Pan X., Hao Y., Zhou M., Lu Z., Gao M., Bao Y., Jia

W. Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease. Cardiovasc. Diabetol. 2013;12:124. doi: 10.1186/1475-2840-12-124. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

113. Haukeland J.W., Dahl T.B., Yndestad A., Gladhaug I.P., Løberg E.M., Haaland T., Konopski Z., Wium C., Aasheim E.T., Johansen O.E., et al. Fetuin A in nonalcoholic fatty liver disease: In vivo and in vitro studies. Eur. J. Endocrinol. 2012;166:503–510. doi: 10.1530/EJE-11-0864. [PubMed]

[CrossRef] [Google Scholar]

114. Weikert C., Stefan N., Schulze M.B., Pischon T., Berger K., Joost H.-G., Häring H.-U., Boeing H., Fritsche A. Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke. Circulation. 2008;118:2555–2562. doi: 10.1161/CIRCULATIONAHA.108.814418. [PubMed] [CrossRef] [Google Scholar]

115. Wong V.W.-S., Adams L.A., De Lédinghen V., Wong G.L.-H., Sookoian S. Noninvasive biomarkers in NAFLD and NASH—Current progress and future promise. Nat. Rev. Gastroenterol. Hepatol. 2018;15:461–478. doi: 10.1038/s41575-018-0014-9. [PubMed] [CrossRef] [Google Scholar]

116. Simon T.G., Corey K.E., Cannon C.P., Blazing M., Park J.-G., O’Donoghue M.L., Chung R.T., Giugliano R.P. The nonalcoholic fatty liver disease (NAFLD) fibrosis score, cardiovascular risk stratification and a strategy for secondary prevention with ezetimibe. Int. J. Cardiol. 2018;270:245–252.

doi: 10.1016/j.ijcard.2018.05.087. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

117. El Hadi H., Di Vincenzo A., Vettor R., Rossato M. Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2019;20:2215. doi: 10.3390/ijms20092215. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

118. Ogawa T., De Bold A.J. The heart as an endocrine organ. Endocr. Connect. 2014;3:R31–R44. doi: 10.1530/EC-14-0012. [PMC free

article] [PubMed] [CrossRef] [Google Scholar]

119. Wu Y.-S., Zhu B., Luo A.-L., Yang L., Yang C. The Role of Cardiokines in Heart Diseases: Beneficial or Detrimental? BioMed Res. Int. 2018;2018:1–14. doi: 10.1155/2018/8207058. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

120. Shimano M., Ouchi N., Walsh K. Cardiokines: Recent progress in elucidating the cardiac secretome. Circulation. 2012;126:e327–e332. doi: 10.1161/CIRCULATIONAHA.112.150656. [PubMed] [CrossRef] [Google Scholar]

121. Rashed H.M., Nair B.G., Patel T.B. Regulation of hepatic glycolysis and gluconeogenesis by atrial natriuretic peptide. Arch. Biochem. Biophys. 1992;298:640–645. doi: 10.1016/0003-9861(92)90460-E. [PubMed]

[CrossRef] [Google Scholar]

122. Jahng J.W.S., Song E., Sweeney G. Crosstalk between the heart and peripheral organs in heart failure. Exp. Mol. Med. 2016;48:e217. doi: 10.1038/emm.2016.20. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

123. Kato T., Niizuma S., Inuzuka Y., Kawashima T., Okuda J., Kawamoto A., Tamaki Y., Iwanaga Y., Soga T., Kita T., et al. Analysis of liver metabolism in a rat model of heart failure. Int. J. Cardiol. 2012;161:130–136. doi: 10.1016/j.ijcard.2011.07.056. [PubMed] [CrossRef] [Google Scholar]

124. Grueter C.E., Van Rooij E., Johnson B.A., DeLeon S., Sutherland L.B., Qi X., Gautron L., Elmquist J.K., Bassel-Duby R., Olson E.N. A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13. Cell. 2012;149:671–683. doi: 10.1016/j.cell.2012.03.029. [PMC free

article] [PubMed] [CrossRef] [Google Scholar]

125. Baskin K.K., E Grueter C., Kusminski C.M., Holland W.L., Bookout A.L., Satapati S., Kong Y.M., Burgess S.C., Malloy C.R., E Scherer P., et al. MED 13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. EMBO Mol. Med. 2014;6:1610–1621. doi: 10.15252/emmm.201404218. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

126. Nakamura M., Sadoshima J. Heart over mind: Metabolic control of white adipose tissue and liver. EMBO Mol. Med. 2014;6:1521–1524. doi: 10.15252/emmm.201404749. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

127. Alter P., Glück T., Figiel J.H., Koczulla A.R., Vogelmeier C.F., Rupp H., Information P.E.K.F.C. From Heart Failure to Highly Unsaturated Fatty Acid Deficiency and Vice Versa: Bidirectional Heart and Liver Interactions. Can. J. Cardiol. 2016;32:217–225. doi: 10.1016/j.cjca.2015.05.019. [PubMed] [CrossRef] [Google Scholar]

128. Jobe L.J., Meléndez G.C., Levick S.P., Du Y., Brower G.L., Janicki J.S. TNF-alpha inhibition attenuates adverse myocardial remodeling in a rat model of volume overload. Am. J. Physiol. Circ. Physiol. 2009;297:H1462–H1468. doi: 10.1152/ajpheart.00442.2009. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

129. Cagli, K.; Ba¸sar, F.N.; Tok, D.; Turak, O.; Ba¸sar, Ö.; Ça ˘glı, K. How to interpret liver function tests in heart failure patients? Turk. J. Gastroenterol. 2020, 26, 197–203. [CrossRef] [PubMed]

130. Hilscher, M.; Sanchez, W. Congestive hepatopathy. Clin. Liver Dis. 2016, 8, 68–71. [CrossRef] [PubMed]

131. Fouad, Y.M.; Yehia, R. Hepato-cardiac disorders. World J. Hepatol. 2014, 6, 41–54. [CrossRef] [PubMed]

132. Alvarez, A.M.; Mukherjee, D. Liver Abnormalities in Cardiac Diseases and Heart Failure. Int. J. Angiol. 2011, 20, 135–142. [CrossRef]

133. Lautt, W.W.; Greenway, C.V. Conceptual review of the hepatic vascular bed. Hepatology 1987, 7, 952–963. [CrossRef] [PubMed]

134. Lautt, W.W. Hepatic circulation: Physiology and pathophysiology. In Colloquium Series on Integrated Systems Physiology: From Molecule to Function; Morgan & Claypool Publishers: California, CA, USA, 2009; Volume 1,

pp. 1–174.

135. Kiernan, F. XXIX. The anatomy and physiology of the liver. Philos. Trans. R. Soc. Lond. 1833, 123, 711–770. [CrossRef]

136. Sherlock, S. The Liver in Heart Failure Relation of Anatomical, Functional, and Circulatory Changes. Heart 1951, 13, 273–293. [CrossRef] [PubMed]

137. Weisberg, I.S.; Jacobson, I.M. Cardiovascular Diseases and the Liver. Clin. Liver Dis. 2011, 15, 1–20. [CrossRef]

138. Asrani, S.; Asrani, N.S.; Freese, D.K.; Phillips, S.D.; Warnes, C.A.; Heimbach, J.; Kamath, P.S. Congenital heart disease and the liver. Hepatology 2012, 56, 1160–1169. [CrossRef]

139. Naschitz, J.E.; Slobodin, G.; Lewis, R.J.; Zuckerman, E.; Yeshurun, D. Heart diseases affecting the liver and liver diseases affecting the heart. Am. Hear.

J. 2000, 140, 111–120. [CrossRef]

140. Samsky, M.D.; Patel, C.B.; DeWald, T.A.; Smith, A.D.; Felker, G.M.; Rogers, J.G.; Hernandez, A.F. Cardiohepatic interactions in heart failure: An overview and clinical implications. J. Am. Coll. Cardiol. 2013, 61, 2397–2405. [CrossRef]

141. Gao, M.; Cheng, Y.; Zheng, Y.; Zhang, W.; Wang, L.; Qin, L. Association of serum transaminases with short-and long-term out-comes in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. BMC Cardiovasc. Disord. 2017, 17, 1–8. [CrossRef] [PubMed]

142. Oh, P.C.; Eom, Y.S.; Moon, J.; Jang, H.-J.; Kim, T.-H.; Suh, J.; Kong, M.G.;

Park, S.-D.; Kwon, S.W.; Choe, J.Y.; et al. Prognostic impact of the combination of serum transaminase and alkaline phosphatase determined in the emergency room in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. PLoS ONE 2020, 15, e0233286. [CrossRef] [PubMed]

143. Moon, J.; Kang, W.; Oh, P.C.; Seo, S.Y.; Lee, K.; Han, S.H.; Ahn, T.; Shin, E.

Serum transaminase determined in the emergency room predicts outcomes in patients with acute ST-segment elevation myocardial infarction who undergo primary percutaneous coronary intervention. Int. J. Cardiol. 2014, 177, 442–447. [CrossRef]

144. Huseynov, A.; Baumann, S.; Becher, T.; Koepp, J.; Lang, S.; Jabbour, C.; Behnes, M.; Borggrefe, M.; Akin, I. Liver and cholestatic pa-rameters as prognostic biomarkers of in-hospital MACE in patients with STEMI. Eur. J. Clin. Investig. 2016, 46, 721–729. [CrossRef]

145. Kim, J.G.; Chang, K.; Choo, E.H.; Lee, J.-M.; Seung, K.-B. Serum gamma-glutamyl transferase is a predictor of mortality in patients with acute myocardial infarction. Medicine 2018, 97, e11393. [CrossRef]

146. Nikolaou, M.; Parissis, J.; Yilmaz, M.B.; Seronde, M.-F.; Kivikko, M.; Laribi, S.; Paugam-Burtz, C.; Cai, D.; Pohjanjousi, P.; Laterre, P.-F.; et al. Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure. Eur. Heart J. 2013, 34, 742–749. [CrossRef]

147. Poelzl, G.; Ess, M.; Von der Heidt, A.; Rudnicki, M.; Frick, M.; Ulmer, H. Concomitant renal and hepatic dysfunctions in chronic heart failure: Clinical implications and prognostic significance. Eur. J. Intern. Med. 2013, 24, 177–182. [CrossRef] [PubMed]

148. Møller, S.; Henriksen, J.H. Cirrhotic cardiomyopathy: A pathophysiological review of circulatory dysfunction in liver disease. Heart 2002, 87, 9–15. [CrossRef]

149. Møller, S.; Bendtsen, F. The pathophysiology of arterial vasodilatation and

hyperdynamic circulation in cirrhosis. Liver Int. 2018, 38, 570–580. [CrossRef]

150. Sampaio, F.; Pimenta, J.; Bettencourt, N.; Fontes-Carvalho, R.; Silva, A.P.; Valente, J.; Bettencourt, P.; Fraga, J.; Gama, V. Systolic and diastolic dysfunction in cirrhosis: A tissue-Doppler and speckle tracking echocardiography study. Liver Int. 2013, 33, 1158–1165. [CrossRef] [PubMed]

151. Ruíz-Del-Árbol, L.; Achécar, L.; Serradilla, R.; Rodríguez-Gandía, M.Á.; Rivero, M.; Garrido, E.; Natcher, J.J. Diastolic dysfunction is a predictor of poor outcomes in patients with cirrhosis, portal hypertension, and a normal creatinine. Hepatology 2013, 58, 1732–1741. [CrossRef]

152. Parekh, N.K.; Hynan, L.S.; De Lemos, J.; Lee, W.M.; Acute Liver Failure Study Group. Elevated troponin I levels in acute liver fail-ure: Is myocardial injury an integral part of acute liver failure? Hepatology 2007, 45, 1489–1495. [CrossRef]

153. Wu, T.T.; Yuan, A.; Chen, C.Y.; Chen, W.J.; Luh, K.T.; Kuo, S.H.; Lin, F.Y.;

Yang, P.C. Cardiac troponin I levels are a risk factor for mor-tality and multiple organ failure in noncardiac critically ill patients and have an additive effect to the APACHE II score in outcome prediction. Shock 2004, 22, 95–101. [CrossRef]

154. Lofthus, D.M.; Stevens, S.R.; Armstrong, P.W.; Granger, C.B.; Mahaffey, K.W. Pattern of liver enzyme elevations in acute ST-elevation myocardial infarction. Coron. Artery Dis. 2012, 23, 22–30. [CrossRef] [PubMed]

155. Lazzeri, C.; Valente, S.; Boddi, M.; Mecarocci, V.; Chiostri, M.; Gensini, G.F. Clinical and prognostic significance of increased liver en-zymes in ST-elevation myocardial infarction. Int. J. Cardiol. 2014, 177, 543–544. [CrossRef] [PubMed]

1. Al-wesabi, Muneer. (2012). The Role of Quality Systems in Improving the Performance of Healthcare Facilities in Yemen: A Case Study of the 48 Model Hospital. https://doi.org/10.13140/RG.2.2.12720.32009

2. Al-wesabi, Muneer. (2017). The Effect of Health Human Resources Development on the Efficacy of Applying Accreditation Standards in Yemeni Hospitals: A Field Study. https://doi.org/10.13140/RG.2.2.28658.67527

3. Al-Wesabi, M., & Shamlan, M. (2022). The Effect of Applying Infection Prevention and Control Standards in Sana’a Governorate Hospitals at the Level of Reducing the Spread of Diseases and Epidemics. Journal of 21 September University for Medical and Applied Sciences, 1(1). https://doi.org/10.65693/masj.2022.v1i1.17

4. Alyahawi, A., Al-Wesabi, M., & ALKaf, A. (2022). Antimicrobial susceptibility of Acinetobacter clinical isolates among ICU Patients in Sana’a City, Yemen. Journal of 21 September University for Medical and Applied Sciences, 1(1). https://doi.org/10.65693/masj.2022.v1i1.14

5. Al-Wesabi, M. (2020). The reality of the Yemeni health sector and the role of September 21 University for Medical and Applied Sciences in reforming it and building the modern Yemeni state (M. Dael, Trans.). Institutional Repository for Scientific Scholarship at 21 September University for Medical and Applied Sciences, 1(1), 106-133. https://doi.org/10.65693/irss.2020.v1i1.47

6. Alyahawi, A., & Al-Wesabi, M. (2020). A study of medication use within insured patients with chronic diseases. Institutional Repository for Scientific Scholarship at 21 September University for Medical and Applied Sciences, 1(1), 72273-72281.

Downloads

Published

2022-12-28

Issue

Section

Scientific Scholarship of Faculty and Students of the Faculty of Clinical Pharmacy at 21 September University for Medical and Applied Sciences

Categories

How to Cite

Al-Awdi, S., Alkhuli, A., Rishan, A., Baker, I., khawez, A., Al Quaish, O., khawez, A., Badi, G., Alboukair, S., Mahdi, A., Modhish, L., Al Sayaghi, T., Qasim, H., & Alazazi, N. (2022). Cardiohepatic Syndrome among Heart Failure Patients in Yemen. Institutional Repository for Scientific Scholarship at 21 September University for Medical and Applied Sciences, 3(1), 1-94. https://doi.org/10.65693/irss.2022.v3i1.305

Similar Articles

21-30 of 77

You may also start an advanced similarity search for this article.